منابع مشابه
Oxidized Hemoglobin Is Antigenic and Immunogenic in Lupus
Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this sequestered, inflammatory molecule can result in deleterious immunological consequences, particularly in the context of pre-existing lupus. IgG ant...
متن کاملOn the Antigenic Properties of Hemoglobin
Sera produced by immunization with crystalline oxyhemoglobin react species-specifically with hemoglobin solutions. Evidence is presented that in this reaction the hemoglobin itself is the active substance. Conversion of oxyhemoglobin into methemoglobin, carbon-monoxy hemoglobin, or cyanhemoglobin does not alter the response to the precipitating immune serum. Not only the hemoglobin of homologou...
متن کاملRapid Publications Glucosylated Collagen Is Antigenic
Sera from rats inoculated with in vitro glucosylated rat skin acid-soluble collagen were evaluated for specific antibody response using the enzyme-linked immunosorbent assay. The data indicate that the altered protein is capable of eliciting the production of antibodies, but unmodified collagen is not. The specificity of the generated antibodies appears to be directed toward the glucitollysine ...
متن کاملHemoglobin D is the Commonest Hemoglobinopathy in the North of Iran
Abstract Background and Objective: Normal hemoglobin (Hb) is formed of a heme group and a protein group known as globin. Globin is made of four polypeptide chains and in hemoglobinopathies, the structure of one of these four polypeptide chain becomes abnormal. Cellulose acetate method is a common way to differentiate haemoglobinopathies. Inabilit...
متن کاملDifferences in antigenic specificity of human normal adult, fetal, and sickle cell anemia hemoglobin.
By MORRIS GOODMAN, PH.D.* AND DAN H. CAMPBELL, Pn.D. T HE DEMONSTRATION by Pauling et al.’ that sickle cell anemia hemoglobin has a slightly higher isoelectric point (0.2 pH unit) than normal human adult hemoglobin and the reports of differences in ability to form nematic liquid crystals2 and solubility differences in strong salt solutions3 suggest that differences might also exist in immunoche...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 1919
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/25.3.207